It doesn't have to be a good story with a happy ending, in fact – the bad stuff is just as riveting to hear, it's also just as helpful. In humans, radiation damages the DNA of our cells, which then mutate and may ultimately become cancerous. "Magisterial... Reading The Emperor of All Maladies is a sharpening, clarifying, and moving experience.... One of the best reading experiences of my life. It is very heavy and not all of it is equally fascinating, but it all hangs together in the end and has given me a proper education in genes, dna, mutations, what cancer actually is and why it has been so impossible to find a panacea. It still took me another month or so to complete the book. This is the second step in the development of cancerous cells, as this renegade cell may now multiply as it pleases, eventually developing into cancerous tissue. When someone we know is diagnosed we talk in terms of prognosis and how much time we/they have left or our odds of beating it. In a brick building on the far corner of Children's Hospital, in Farber's own backyard, a microbiologist named John Enders was culturing poliovirus in rolling plastic flasks, the first step that culminated in the development of the Sabin and Salk polio vaccines. That he manages this without alienating people who come to the material with no more knowledge than one could glean from newspaper articles and high school biology is impressive.
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There's a history of our knowledge of cancer and also a history of the scientific and medical attempts to combat it. In practice, however, Democedes lacked two things that we take for granted in surgery today: anesthesia and sufficient hygiene! He wrote a marvelous study on the classification of children's tumors and a textbook, The Postmortem Examination, widely considered a classic in the field. Dr. Mukherjee writes with grace and elegance about a topic that strikes fear like little else and takes the reader from a horrifying history, the effects of which still linger and haunt, to the fever-pitched decades of discovery, experimentation, fearlessness and compassion, to where we are now, which I am convinced is the cusp of medicine's finest hour. What were probably missing in the book- global focus or progress in developing world; a specialised & separate index of illnesses mentioned and scientists which would have made it easier to tackle some cross references happening through out the book. Mukherjee is thorough with his story and writes pretty well, although the focus is very much on the American scene, with researchers from Europe and elsewhere sometimes dealt with in a cursory fashion; at one point he even describes France and England as lying on the 'far peripheries' of medicine! I often love books by doctor writers and I'll definitely read (almost) all other books this author writes. The Emperor of All Maladies Key Idea #5: Radiation, hormones and hereditary influences all increase your cancer risk. Firstly, germs may indirectly give rise to cancerous cells. Though a big dense book, with tons of information, it is greatly written and explained in a way everyone can understand.
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If cancer treatment today seems a complicated process, imagine trying to treat it back in 500 BCE! Every growing human tissue could be described in terms of hypertrophy and hyperplasia. I'm not sure if it qualifies as a biography of cancer per se and I only mentioned this because I kind of feel ambivalent about the anthropomorphizing of cancer through out the book. The most discouraging sections of the book were about smoking and the nation's reluctance to warn of the high risk of lung cancer. Shotgun blast medicine that's the most expensive in the world. The writing is generally adequate, if a little verbose, though one tic of the author's drove me nuts. I kept it on the kitchen counter and as the left-hand page pile got bigger there was me standing on the right, getting smaller. Pure and simple it is a scary way to have to live life. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. Actually, I guess that's already evident from the book's title. Cancer cells can grow faster, adapt better.
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And sitting in his basement laboratory in the summer of 1947, Farber had a single inspired idea: he chose, among all cancers, to focus his attention on one of its oddest and most hopeless variants—childhood leukemia. Cancer is a collective noun for hundreds of diseases, and every time we think we have figured out one tiny piece of the puzzle for one of those diseases, cancer races ahead of us, adapting and evolving to wreak havoc again, undisturbed for yet another decade. While most damaged cells die, a few will live on, accumulate more damage and become cancerous. Bennett's earlier fantasy had germinated an entire field of fantasies among scientists, who had gone searching (and dutifully found) all sorts of invisible parasites and bacteria bursting out of leukemia cells.
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Every last morsel of energy is spent tending to the disease. Instead of normal white cells, her blood was packed with millions of large, malignant white cells—blasts, in the vocabulary of cancer. Pick up the key ideas in the book with this quick summary. This was a book group book and I worried that some would find the topic overally depressing to read or that others, cancer survivors themselves, might be emotionally upset. Patients tell stories to describe illness; doctors tell stories to understand it. Cool, composed, and cautious. And he has an ear to quote others. What I was doing was either boiling the kettle or making my own concoction of a fat and cholesterol-busting mousse that involved just holding an immersion whisk for a couple of minutes. And with the rise in medical care came the concomitant expectation of medical cure. Her chances of being cured were about 30 percent, a little less than one in three.
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I laid out the odds. A magisterial, wise, and deeply human piece of writing. He gives us a sweeping look at the beginning treatments, trials, operations, and research. As a doctor learning to tend cancer patients, I had only a partial glimpse of this confinement. —San Francisco Chronicle.
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I had a novice's hunger for history, but also a novice's inability to envision it. THIS EDITION INCLUDES A NEW INTERVIEW WITH THE AUTHOR. And, being both male and American, I have done my share of dumb things. Since I was even then interested in Darwinism, I remember thinking "natural selection wants me out". In acute lymphoblastic leukemia, as in some other cancers, the overproduction of cancer cells is combined with a mysterious arrest in the normal maturation of cells. Sheet upon sheet of malignant blasts packed the marrow space, obliterating all anatomy and architecture, leaving no space for any production of blood. Even tuberculosis, the infamous. Among human diseases. He eventually convinced her to let him cut out the lump, thereby healing her. I wanted to dislike this book.
By investigating tumor tissue under a microscope, he discovered that it was in fact composed of a vast number of the body's own cells. This may seem harsh, but diagnosis is a lost art. And in short, I was afraid. Cancer begins and ends with people. Outspoken, pugnacious, and bold. She would later recall.
But here: myc, neu, fos, ret, akt (all oncogenes), and p53, VHL, APC (all tumor suppressors). On every page are patients suffering through cancer and its treatments, losing their battle only a few chapters before the particular solution they needed is found. In every case, cells had all acquired the same characteristic: uncontrollable pathological cell division. Then again, one of Mukherjee's major points is that "cancer" is a collection of protean, complex, multifaceted things, evolution in situ possessing its own elegance and beauty, a noble and almost clever opponent. As the technician drew a tube of blood from her vein, he looked closely at the blood's color, obviously intrigued. It invaded our imaginations; it occupied our memories; it infiltrated every conversation, every thought. He is an assistant professor of medicine at Columbia University and a staff cancer physician at Columbia University Medical Center. Soon the slate-layer was on the verge of death with more swollen tumors sprouting in his armpits, his groin, and his neck. Worth it for the chapter quotes. Some mornings, exhausted and unable to stand up, she crawled down the hallways of her house on all fours to get from one room to another. The body invaded by leukemia is pushed to its brittle physiological limit—every system, heart, lung, blood, working at the knife-edge of its performance. ArtThe Journal of medical humanities. And so, Farber had decided to make a drastic professional switch.
Once it actually develops, your options remain fairly limited, and the metric of success is still often how many years of remission one can hope for, rather than the chances of an outright 'cure'. Perhaps it was a migraine, she suggested, and asked Carla to try some aspirin. Wealthy, gracious, and enterprising. 2 million deaths in 2012 alone. A solitary malignant lump in the breast, say, could be removed via a radical mastectomy pioneered by the great surgeon William Halsted at Johns Hopkins in the 1890s. A labor of love… as comprehensive as possible. It seems that during my college years my body's usual self-commanding mechanism, in a distinct area, stopped working properly i. e. my typical cell cycle malfunctioned.
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