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Multiple Choice (choose the best answer). Typically, acquired warm autoimmune hemolytic anemia, which produces positive Coombs test results, can cause spherocytes as well; however, the history of lifelong anemia makes this diagnosis unlikely. Older age is a risk factor for AML, and AML is more common in males than females. The serum creatinine, electrolytes, and liver function tests were normal. D. Hematology Case Studies (made up) Flashcards. Worsening heart failure.
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Some studies suggest that it can be found in nearly three-quarters of individuals older than the age of 90 years if a sensitive threshold is used for identification of B-cell clones. When she returned to her family doctor, she reported that the pain was a little better but had not gone away. Most patients have a disseminated lymphoproliferative disease at the time of diagnosis, but some patients have a localized lymphoproliferative disorder and some an autoimmune condition. Hematology Questions and Answers | Mayo Clinic Internal Medicine Board Review Questions and Answers | Oxford Academic. Two-dimensional gel electrophoresis revealed a μ heavy chain, and a 24-hour urine contained a monoclonal κ protein of 0. Dimorphic erythrocyte population with pronounced macrocytes.
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Switching to dabigatran would result in inferior outcomes. 2012 Mar;97(3):388-92. doi: 10. He had been a heavy smoker until 2 years previously but had now stopped. A combination of carmustine, daunorubicin, vincristine, and prednisone was recommended, but the patient died before the new regimen could be instituted. In general, apart from the marrow morphology, which of the following features strongly suggests a diagnosis of WM rather than IgM myeloma? A. MCL is twice as common in males as in females. He has patches and plaques covering less than 10% TBSA with no lymph node, visceral, or blood involvement. It looks like your browser needs an update. Therefore, it is imperative to ensure normal renal function before their use. Hematology questions and answers pdf. Test: DAT aka direct coombs test to see if this is an immune hemolytic anemia. The patient's initial symptoms of morning stiffness had spontaneously resolved. The staging investigations confirm Ann Arbor stage I. Which of the clinical, biological, or imaging factors do not suggest histologic transformation? He had no peripheral lymphadenopathy.
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Marginal Zone B-Cell Lymphomas Case 2. If the patient is found to have had hepatitis B, it is advisable to consult with a hepatologist before administration of immunosuppressive agents. Flow cytometry of his blood showed characteristic immunophenotypic markers of hairy cell leukemia (CD20+, CD11c+, CD25+, CD103+, CD123+). The diagnosis was affirmed by the finding of a t(8;14)(q24;q32) within the marrow cell sample, and a gene expression profile (GEP) revealed a typical BL molecular pattern. A 72-year-old man of European descent had a routine medical examination as a prelude to taking out a life insurance policy. The hemolysis is predominantly intravascular. Answer e. Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder of mature lymphocytes. Autoimmune conditions, including AIHA and immune thrombocytopenia, are frequent after fludarabine therapy, possibly caused by depression of regulatory T cells. A significant minority of patients have bone disease with lytic lesions and there may also be osteoporosis. BCL2 is strongly positive. C. Hematology case studies with answers pdf book. If ONJ occurs, bisphosphonate therapy should be stopped. Complete surgical resection if technically feasible. These included a plasma urea and electrolytes, liver function tests, and calcium and phosphate levels, all of which were normal.
The bilirubin was raised at 42 μmol/L with only 10% conjugated. Emergent plasmapheresis (for hyperviscosity sx). 8 × 109/L, atypical lymphocytes were 0. Hematology case studies with answers pdf downloads. Laboratory studies are notable for a leukocytosis with white blood cell count of 20. She elected not to have her implants replaced. Mean corpuscular volume, fL. His father had been diagnosed with chronic lymphocytic leukemia (CLL) at age 75 years and died at the age of 78 years from a cerebrovascular event. In intravascular hemolysis, the urine is positive for hemoglobin. A marrow biopsy is important to determine the extent of residual disease.
Platelets are thought to be contraindicated in TTP because of the theoretical possibility of worsening the TTP. It is more common in males. BV is an antibody that binds to CD30. Two-dimensional electrophoretic analysis confirmed the diagnosis of α heavy chain disease (αHCD). Myelosuppression is a common complication, but it can usually be dealt with by brief drug discontinuation and dose reduction. 21-Year-Old With Duodenal Adenocarcinoma and a History of T- cell Lymphoma.