Then we analyzed the enrichment and expression of key target genes in the database. Liu, P., Shang, E. X., Zhu, Y., Yu, J. G., Qian, D. W., and Duan, J. Of many possible clinical applications, it may be considered to influence the following issues/symptoms: Ge Xia Zhu Yu Wan has some precautions to be considered (see our precautions list). Sometimes Qi Deficiency, Blood Deficiency and Phlegm can also be the precursors. Shi Xiao San Ameliorates the Development of Adenomyosis in an ICR Mouse Model. Liver tissue slices were cultured in primary antibody, a-SMA antibody (1:500), and anti-CD68 (1:100) at 4°C overnight and then cultured in secondary antibodies, goat anti-rabbit IgG antibody (1:100), and goat anti-mouse IgG (1:100) conjugated at room temperature for 2 h. And the sections of different groups were photographed by using a multifunctional confocal microscope (Olympus, Tokyo, Japan). 5 and limited to Homo sapiens species. Feitelson, M. Ge xia zhu yu tang for dogs. A., Reis, H. M., Tufan, N. L., Sun, B., Pan, J., and Lian, Z. Its main actions are: 1) invigorates Blood and 2) eliminates Blood Stagnation below the diaphragm. Indications: Blood stasis below the diaphragm.
Ge Xia Zhu Yu Tang
The expression of the key target genes was analyzed in GSE6764 dataset (Wurmbach et al., 2007). The hematoxylin and eosin (HE) staining were purchased from Beijing Zhongshan Goldenbridge Biotechnology Co. LTD (ZLI-9613, Beijing, China). Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. The pathway enrichment results suggested that the key targets were mostly involved in pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway (Figure 3A). 2023 Crane Herb Company. MAPK signaling pathway promotes the proliferation and activation of HSC (Pan et al., 2019) (Peng et al., 2013), and can also stimulate the production of collagen (Cao et al., 2006). A range of pain related issues when they arise from qi and blood stagnation (both acute and chronic) - pain essentially anywhere in the body, bruises and swelling and other signs of stasis. Removes blood stasis. Hypochondriac distention. Product Page: Stores_Product_Widget. Ge Xia Zhu Yu Tang - Capsules (100 count). XC, HC, and RL conducted the cell experiments. Sanctions Policy - Our House Rules. Should not be used for qi stagnation without blood stasis. With Dang Gui, tonifies Blood and moves Qi, for premenstrual symptoms, menstrual pain and irregular menstruation.
Ge Xia Zhu Yu Tang For Dogs
With Xiang Fu and Yan Hu Suo, for chest and epigastric pain due to Qi and Blood Stagnation. T000800263, Jiangxi, China; 5g), Cyperi Rhizoma (Xiangfu in Chinese, No. In the context of Ge Xia Zhu Yu Tang, it is used because it invigorates Blood, eliminates Stagnation and stop pain. Enriched KEGG pathways of key target genes. Ru, J., Li, P., Wang, J., Zhou, W., Li, B., Huang, C., et al. Relieve constipation. Dimethyl Fumarate Targets GAPDH and Aerobic Glycolysis to Modulate Immunity. Plasters (Gao) and Patches. Tu, C. Ge xia zhu yu tang. T., Guo, J. S., Wang, M., and Wang, J. Y. T001200729, Hebei, China; 9g), Moutan Cortex (Mudanpi in Chinese, No. Chen et al., 2020), Moutan Cortex (the dried bark of Paeonia suffruticosa Andr. ) Formulas & Strategies. Based on the fact that BC, CNC, DC, LAC, NC, and SC are above the median (BC > 0. Moistens intestines, unblock bowels - constipation due to ….
Ge Xia Zhu Yu Tang Bee
Nucleic Acids Research 43, D789–798. Japanese Name: Unit Size: 100 gm. With Xiang Fu and Dang Gui, for dysmenorrhea from Qi Stagnation and Blood Stasis. We found that the mechanisms of GXZY may be related to the pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway derived from network pharmacology analysis. The scratch areas were quantified using Imagepro-plus 6. Most of the herbs in the formula have shown some anti-cancer properties in studies (human or animal)…. Conglomerations and. Ge xia zhu yu tang bee. Cools the Blood and the Liver. The remaining rats were gavaged at 1 ml/100 g once a day from the ninth week. You may also see this formula referenced by: Ge Xia Zhu Yu Tang, Persica and Carthamaus Combination, Tangkuei and Corydalis Combination. Sets found in the same folder. Moreover, in the present study, GXZY is also used in treating clinical chronic liver diseases such as liver fibrosis and cirrhosis, and it is reported that GXZY exhibited an excellent anti-liver fibrosis effect in treating chronic hepatitis B (CHB) (Hui, 2016) (Ma, 2015).
Ge Xia Zhu Yu Tang Powder For Dogs
STRING V11: Protein-Protein Association Networks with Increased Coverage, Supporting Functional Discovery in Genome-wide Experimental Datasets. Peng, Y., Yang, H., Zhu, T., Zhao, M., Deng, Y., Liu, B., et al. Ge Xia Zhu Yu Wan | Stasis in the Lower Chamber Teapills. With Yan Hu Suo, Chao Wu Ling Zhi, Hong Hua and Xiang Fu, for Blood Stagnation in the hypochondrium. Been evaluated by the Food and Drug Administration. Invigorates the Blood, unblocks menstruation, opens the channels, dispels Blood Stasis and alleviates pain. The economic sanctions and trade restrictions that apply to your use of the Services are subject to change, so members should check sanctions resources regularly. And compared to normal liver tissues, the expression of AR, JUN, MMP9, GAPDH, and RELA had significant change in LC patients (Figure 2D).
Ge Xia Zhu Yu Tanguy
It is now believed that timely and aggressive treatment of liver fibrosis can inhibit or even reverse the development of cirrhosis (Schuppan et al., 2018; Roehlen et al., 2020), although the etiological treatment of western medicine can help to inhibit or even reverse LC, such as long-term anti-hepatitis B virus (HBV) treatment. Angelicae Sinensis, Rz. On the right of experimental validation, rat animal experiments proved that GXZY inhibiting LC by affecting liver injury, inflammatory and collagen fibers. In general Xiang Fu's main actions are as follows: "Unblocks Stagnant Liver Qi and relieves pain. Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy. In conclusion, through the combination of network pharmacology and experimental verification, this study offered more insight molecular mechanisms of GXZY on LC. Enriched molecular function of key genes. NC Neighbor Connectivity.
And the key targets were significantly related to multiple GO-BP, including response to drug, negative regulation of apoptotic process, and positive regulation of transcription, DNA-templated (Figure 3B). ALT, AST, and ALP of serological index rats were increased after 8 weeks CCl4 modeling. Electrophoresis 41, 1606–1616. Combined with the experimental results of animals and cells, this study found that GXZY can inhibit the progression of liver cirrhosis. Also are well known for their empirical ability to stop pain. Qi is one of Chinese Medicine's vital subtances. For post surgery recovery. The purple circles represent key target genes. Serve with warm water on an empty stomach, 2-3 hours apart from your. The qRT-PCR results showed that the expression of Tnf and Il6 was very low in the control group. Hoehes33342 counterstained the nucleus, and the fluorescence was blue.
0001 versus the control group. Possible dark, purplish. We may disable listings or cancel transactions that present a risk of violating this policy. Below the Diaphragm Dispel. Decoct in water for oral dose to be taken twice. You shouldn't use it for the purpose of self-diagnosing or self-medicating but rather so you can have a more informed discussion with a professional TCM practitioner. Subclass: Disperse Blood Stasis. Q., Chen, H. -W., Li, J., and Wu, Q. Accordingly, inhibition of the progression of hepatic fibrosis by suppressing HSCs proliferation and activation and production of collagen via MAPK signaling pathway. The images are presented at low power (× 200, Scale bars = 100 μm, n = 3). The typical symptoms of Qi stagnation are distension, oppression and swelling. The relationship between key compounds and key genes was shown in Supplementary Table S6.
Piñero, J., Ramírez-Anguita, J. M., Saüch-Pitarch, J., Ronzano, F., Centeno, E., Sanz, F., et al. LiemingXu-2 (LX-2) is human hepatic stellate cells (HSC) identified by cell line and maintained in dulbecco's modified eagle medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 100 U/ml penicillin, 100 μg/ml streptomycin, and 5% CO2. The control and the model groups were given distilled water gavage, and the GXZY group was given a clinically equivalent dose of GXZY solutions by gavage. Nourishes the blood so as to prevent damaging the blood by over-attacking and. The Effect of Gexia Zhuyu Tang. The mRNA expression levels of MMP9, CASP3, and GAPDH for LX-2 cells. Inhibiting the production and deposition of ECM and promoting its degradation is an important strategy for treating hepatic fibrosis (She et al., 2020).
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