Previous network pharmacological studies had also found that AR and MYC could play a key role in the process of viral hepatitis, liver cirrhosis, and liver cancer (Huang et al., 2012) and inhibit the expression of AR (Kur et al., 2020), JUN (Vogt, 2001), and MYC (Wu et al., 2020), which reduce the occurrence of liver cancer. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Gexia-Zhuyu Decoction (GXZY) is a traditionally classic prescription composed of medicinal plants. Why Evergreen Herbs. 3390/ijerph17082620. Ge Xia Zhu Yu Wan is a candidate for consideration when needing to influence blood stagnation, liver blood stagnation and/or liver qi stagnation. In order to protect our community and marketplace, Etsy takes steps to ensure compliance with sanctions programs. NC Neighbor Connectivity. The qRT-PCR results in rats showed that Mmp9 (Figure 7C) and Ar expression was elevated and Gapdh expression was decreased in the model group compared with the control group, and the expression of other key genes in each group was not statistically significant (Supplementary Figure S1A). Ge xia zhu yu tang side effects. Preparation Experimental Reagent. Data Availability Statement. Subsequently, the potential action mechanisms of GXZY on LC predicted by the network pharmacology analyses were experimentally validated in LC rats and LX2 cells.
Ge Xia Zhu Yu Tang Side Effects
Immunofluorescence histochemistry about correlation and colocalization analysis of α-SMA and CD68 in rat liver tissues. In LX2 cells experiment, GXZY could reduce expression of CASP3, which is consistent with previous studies, and salvianolic acid A could reduce the expressions of CASP3 and liver fibrosis (Wang et al., 2019). Product informations. Pharmaceutical Name: Alternate Name: Tangkuei & Corydalis Combination. LX-2 cells were treated dose-increased GXZY, and the cell viability was detected with CCK-8. Ge Xia Zhu Yu Tang › Veterinarian Recommended Holistic Pet Products. In the context of Ge Xia Zhu Yu Tang, it is used because it invigorates Blood, eliminates Stagnation and stop pain. Removes blood stasis. 1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. With Mu Dan Pi, for pain due to Blood Stasis.
Cao, X., Zao, X., Xue, B., Chen, H., Zhang, J., Li, S., et al. After that, STRING data were imported into the Cytoscape and we deleted targets that lack protein structure and interact without other genes, and got PPI the remaining 525 proteins to further obtain interaction networks. Ge xia zhu yu tang clan. Then we analyzed the enrichment and expression of key target genes in the database. Qi and Blood stagnation blocking the channels and collaterals - pain in the extremities, shoulder pain, elbow pain, leg pain. ORIGINAL RESEARCH article.
Ge Xia Zhu Yu Tanguy
In Chinese Medicine health conditions are thought to arise due to "disharmonies" in the body as a system. The traditional Chinese medicine Gexia-Zhuyu formula (GXZY) has a therapeutic effect on LC. Nourishes the blood so as to prevent damaging the blood by over-attacking and. We use cookies to improve user experience and analyze website traffic. Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy. Extracts of Common Single Herbs. The overlapped genes (OGEs) were the intersection of the GXZY compound-putative targets and LC disease targets.
Qing-ren's Qing dynasty Yi Lin Gai Cuo (Correcting the Errors in the Forest of. A single formula, alone, may not be sufficient to fully address a particular TCM diagnostic pattern. Ge xia zhu yu tanguy. Harmonizes and moderates the effects of other herbs. We found that the mechanisms of GXZY may be related to the pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway derived from network pharmacology analysis.
Ge Xia Zhu Yu Tang Clan
GXZY Gexia-Zhuyu formula. GXZY might be beneficial to the growth of body weight and slow down liver injury in cirrhotic rats. The importation into the U. S. Jing Tang Ge Xia Zhu Yu Concentrated 90g Powder. of the following products of Russian origin: fish, seafood, non-industrial diamonds, and any other product as may be determined from time to time by the U. Network Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Zuojinwan for Treatment of Gastritis. CC Cellular Component. Clear Deficient Fire. T001200349, Xinjiang, China; 9g), Angelicae Sinensis Radix (Danggui in Chinese, No.
Piercing hypochondriac pain. Category: Classic Capsules. Ashburner, M., Ball, C. A., Blake, J. Sin 39 (6), 942–951. TCM is a comprehensive medical system, which plays a significant role in the health maintenance of Asians (Liu et al., 2019; Zhang et al., 2019). Finally, the experiments of Western Blotting and qRT-PCR were used to verify the expression of key target genes. The studies have shown that inhibition of HBV and intrahepatic inflammation can delay or even reverse the progression of cirrhosis.
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Clears Heat and dispels toxicity. Deng, Z., Zhang, S., Ge, S., Kong, F., Cao, S., and Pan, Z. Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells. A Chinese Herbal Medicine, Gexia-Zhuyu Tang (GZT), Prevents Dimethylnitrosamine-Induced Liver Fibrosis through Inhibition of Hepatic Stellate Cells Proliferation. The above drugs were obtained, authenticated, and made into granules by the Beijing Tcmages Pharmaceutical Co., LTD (Beijing, China) under the guidance of Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association, 2020 edition. Previous studies have shown that inflammation and oxidative stress promote the activation of MAPK signaling pathway. After blocking, membranes were incubated with the relevant primary antibodies anti-MMP9 (1:100) at 4°C overnight, and then were incubated with the secondary antibody goat anti-rabbit IgG antibody (1:2, 000) at room temperature for 1 h, ß-actin antibody (1:5, 000) for control. We first analyzed the botanical drugs in GXZY by TCMSP databases and found 22 active components in Honghua, 2 in Danggui, 7 in Chuanxiong, 23 in Taoren, 11 in Mudanpi, 29 in Chishao, 9 in Wuyao, 49 in Yanhusuo, 5 in Zhike, 18 in Xiangfu, 92 in Gancao, and 0 in Wulingzhi, respectively. The GXZT group rats had low collagen fiber deposits in the liver at the 12th week compared with the model group. Li, X., Zhou, D., Chi, X., Li, Q., Wang, L., Lu, B., et al. In general Hong Hua's main actions are as follows: "Moves Stagnant Blood and regulates menses. Pulse type(s): Choppy (Se), Deep (Chen), Fine (Xi). These prepared pieces of botanical drugs were converted into granules, and we obtained a pair of GXZY granules at 16 g, and the specific drug preparation process was shown in Supplementary Table S1. Tea and Instant Beverages.
Compound-Putative Targets in GXZY and Disease Targets in LC. Please see Strategic Dosing Guidelines for details. With Dang Gui, Hong Hua and Chi Shao, for menstrual pain, amenorrhea, irregular menstruation due to Blood Stasis and trauma with pain. The protein expression levels of Mmp9 in rat. Kornberg, M., Bhargava, P., Kim, P., Putluri, V., Snowman, A., and Putluri, N. (2018). With Dang Gui, tonifies Blood and moves Qi, for premenstrual symptoms, menstrual pain and irregular menstruation. FORMULAS THAT INVIGORATE THE BLOOD AND DISPEL BLOOD STASIS: ACTIONS: Invigorates the Blood; Dispels Blood stasis; Promotes the movement of Qi; Alleviates pain INDICATIONS: For Blood stasis in the area below the diaphragm with palpable abdominal masses accompanied by fixed pain, or abdominal masses that are visible when lying down; Also for chronic diarrhea and daybreak diarrhea; Also commonly used to treat amenorrhea and painful periods TONGUE: PULSE: Terms in this set (12). And the results of the cell experiment showed that GXZY could inhibit the proliferation and migration of human HSC. Then, TNF signaling induces biological effects as diverse as cell proliferation, metabolic activation, inflammatory response, and cell apoptotic or necrotic. Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., et al.
Clinical Manifestations. Dizziness, tinnitus, hair loss - with underlying blood stagnation s…. Kur, P., Kolasa-Wołosiuk, A., Misiakiewicz-Has, K., and Wiszniewska, B. MF Molecular Function. In Vitro and In Vivo Assessment of CYP2C9-Mediated Herb-Herb Interaction of Euphorbiae Pekinensis Radix and Glycyrrhizae Radix. Author Contributions. Linderae Radix Ethanol Extract Alleviates Diet-Induced Hyperlipidemia by Regulating Bile Acid Metabolism through Gut Microbiota. Wurmbach, E., Chen, Y. Use with caution during menstruation.
And the key targets were significantly related to multiple GO-BP, including response to drug, negative regulation of apoptotic process, and positive regulation of transcription, DNA-templated (Figure 3B). Invigorates the Blood, unblocks menstruation, opens the channels, dispels Blood Stasis and alleviates pain. One month after GXZY treatment, collagen fiber deposition in liver tissue decreased (Figure 6B), and the difference was statistically significant (Figure 6D). Contraindications (on label): Contraindicated during pregnancy. Sex Hormone-dependent Physiology and Diseases of Liver.
Please log in to view the product information. Tangkuei & Corydalis Combination (blood-regulating formula). Multi-Component Comparative Pharmacokinetics in Rats after Oral Administration of Fructus Aurantii Extract, Naringin, Neohesperidin, and Naringin-Neohesperidin. B., Khitrov, G., Zhang, W., Roayaie, S., Schwartz, M., et al. Pain of all types from qi and blood stagnation - often combined with other more systemic formulas based on the individual. Barcode: 739934933626. Concretions and accumulations. With Dang Gui and Chuan Xiong, for irregular menses and dysmenorrhea due to Qi and Blood Stasis. Liver cirrhosis (LC) develops from liver fibrosis (LF), and LF is a pathological process of collagen-based extracellular matrix (ECM) deposition in the liver (Tsuchida and Friedman, 2017; Kisseleva and Brenner, 2021). 65 g/(kg d) (Reagan-Shaw et al., 2008). The qRT-PCR results in LX2 cells showed that GXZY could reduce the mRNA expression of MMP9, CASP3, and GAPDH compared with the control group (Figure 8D). BC Betweenness Connectivity.
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Kevin Gates Ain't Too Hard Lyrics
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